Modulators of prorenin activity

Details Modulators of prorenin activity Modulators of prorenin activity

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61P 9/12 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2404644

A method of selecting a substance capable of controlling the activation of prorenin with the use of, as an indication, the ability to control the activation of prorenin by an interaction between proteins in the profragment domain of prorenin; a prorenin activation controlling substance which has a function of controlling the activation of prorenin based on the interaction between proteins in the profragment domain of prorenin; and hypotensors, organ overgrowth inhibitors and arterial thickening inhibitors containing the above- described prorenin activation controlling substance as the active ingredient.

La présente invention concerne un procédé de sélection d'une substance capable de réguler l'activation de la prorénine, et notamment capable de réguler l'activation de la prorénine par une interaction entre des protéines du domaine profragmentaire de la prorénine. L'invention concerne également une substance régulant l'activation de la prorénine, et dont la fonction de régulation de l'activation de la prorénine repose sur l'interaction entre protéines du domaine profragmentaire de la prorénine. L'invention concerne enfin des hypotenseurs, des inhibiteurs d'hypertrophie organique, et des inhibiteurs de l'épaississement artériel et dont le principe actif est la substance régulatrice de l'activation de la prorénine selon l'invention.

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