Modulators of retinol-retinol binding protein...

Details Modulators of retinol-retinol binding protein... Modulators of retinol-retinol binding protein...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A01N 31/04 (2006.01)

Patent

CA 2584396

Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex formation. Furthermore, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-~related macular degeneration and/or dystrophies.

Procédés et compositions de détection de la formation d'un complexe rétinol et d'une protéine de liaison rétinol (RBP), transthyretine (TTR). Les procédés et compositions assurent le criblage de modulateurs de la formation complexe rétinol-RBP-TTR. Par ailleurs, les procédés et compositions fournissent des agents thérapeutiques pour le traitement et/ou la prévention de la dégénération maculaire associée à l'âge et/ou de dystrophies.

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