C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 31/713 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61P 19/10 (2006.01)
Patent
CA 2675639
The present invention relates to the use of modulators of the sclerostin: sclerostin- binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders, e.g., osteoporosis and sclerosteosis, and sclerostin-related disorders, e.g., cancers and cardiovascular disorders. The invention also relates to the use of sclerostin-binding-partner mimetics for the treatment, amelioration, and diagnosis of sclerostin-related disorders. Assays for the identification of modulators of the sclerostin: sclerostin-binding-partner interaction, as well as the resulting signaling, are also provided.
La présente invention porte sur l'utilisation de modulateurs de l'interaction sclérostine : partenaire de liaison de la sclérostine pour le traitement, l'amélioration et le diagnostic de troubles liés à la sclérostine, par exemple l'ostéoporose et la sclérostéose, et de troubles liés à la sclérostine, par exemple les cancers et les troubles cardio-vasculaires. L'invention porte également sur l'utilisation de mimétiques de partenaires de liaison de la sclérostine pour le traitement, l'amélioration et le diagnostic de troubles liés à la sclérostine. L'invention porte également sur des analyses pour l'identification de modulateurs de l'interaction sclérostine : partenaire de liaison de la sclérostine, ainsi que sur la signalisation résultante.
Halleux Christine
Hu Shou-Ih
Kneissel Michaela
Lu Chris Xiangyang
Fetherstonhaugh & Co.
Novartis Ag
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