C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2656838
The invention relates to an in vitro method of screening for candidate compounds for the preventive or curative treatment of acne, comprising the determination of the ability of a compound to modulate the expression or the activity of the peroxisomal membrane ATP-binding cassette transporter 1, subfamily D, type 3 (ABCD3), and also to the use of modulators of the expression or of the activity of this transporter for the treatment of acne or of skin disorders associated with hyperseborrhoea. The invention also relates to methods for the diagnosis or prognosis, in vitro, of these pathologies.
L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'acné, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité du transporteur 1 membranaire du péroxisome contenant un site de liaison à l'ATP du type 3 de la sous-famille D (ABCD3), ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de ce transporteur pour le traitement de l'acné ou des désordres cutanés associés à une hyperséborrhée. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de ces pathologies.
Calvo Ezequiel L.
Carlavan Isabelle
Collette Pascal
Deret Sophie
El-Alfy Mohamed
Galderma Research & Development
Robic
LandOfFree
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