Modulators of the cx3cr1 receptor and therapeutic uses thereof

Details Modulators of the cx3cr1 receptor and therapeutic uses thereof Modulators of the cx3cr1 receptor and therapeutic uses thereof

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/02 (2006.01)

Patent

CA 2746976

The present invention concerns modulators of the CX3CR1 receptor. More specifically, antagonists and agonists of the CX3CR1 receptor have been identified. These antagonists and agonists can be used for treating an inflammatory disorder, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a graft versus host disease, a behavioral disorder, a cicatrisation disorder, a viral infection, cancer or pain. They may also be used as an adjuvant in a vaccine composition.

Cette invention concerne des modulateurs du récepteur CX3CR1. L'invention concerne plus spécifiquement l'identification d'antagonistes et d'agonistes du récepteur CX3CR1. Ces antagonistes et agonistes peuvent être utilisés pour traiter un état inflammatoire, une maladie auto-immune, une maladie cardiovasculaire, une maladie neurodégénérative, la réaction du greffon contre l'hôte, un trouble du comportement, un problème de cicatrisation, une infection virale, le cancer ou la douleur. Ils peuvent également être utilisés en tant qu'adjuvant dans une composition vaccinale.

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