Modulators of the function of fas receptors and other proteins

Details Modulators of the function of fas receptors and other proteins Modulators of the function of fas receptors and other proteins

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 14/81 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2226973

The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided as well as a method of designing them.

La présente invention se rapporte à des protéines capables de moduler ou d'induire la fonction du ligand du récepteur FAS ou l'effet du facteur de nécrose tumorale (TNF) sur des cellules porteuses du récepteur FAS ou du récepteur p55 par une liaison ou interaction avec la protéine MORT-1 qui, à son tour, se fixe au domaine intracellulaire du récepteur FAS ou à une autre protéine TRADD qui se fixe au récepteur p55. L'invention se rapporte de plus à des inhibiteurs peptidiques qui interfèrent avec l'activité protéolytique des protéines de liaison de MORT-1 ainsi qu'à leur conception.

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