Modulators of the h3 receptor useful for the treatment of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 209/52 (2006.01) A61K 31/403 (2006.01) A61K 31/422 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/10 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2628527

The present invention relates to certain fused heterobicyclic derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, motion sickness and vertigo, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.

La présente invention a trait à certains dérivés hétérobicycliques fusionnés de formule (Ia) et à des compositions pharmaceutiques en contenant qui sont modulateurs de l'activité du récepteur H3. Des composés et des compositions pharmaceutiques en contenant sont utilisés dans des procédés pour le traitement de troubles associés à H3, tels que des troubles cognitifs, l'épilepsie, le traumatisme crânien, la dépression, l'obésité, le mal de mouvement et le vertige, des troubles du sommeil et l'état de veille tels que la narcolepsie, le syndrome de travail par roulement, l'endormissement en tant qu'effet secondaire d'une médication, le maintien de vigilance pour assister dans la réalisation de tâches et analogues, la cataplexie, l'hypersomnie, le syndrome de somnolence, le syndrome de décalage horaire, l'apnée du sommeil et analogues, l'hyperactivité avec déficit de l'attention, la schizophrénie, des allergies, des réactions allergiques dans la voies supérieures, la rhinite allergique, la congestion nasale, la démence, la maladie d'Alzheimer et analogues.

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