C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C12N 9/10 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2656842
The invention relates to an in vitro method of screening for candidate compounds for the preventive or curative treatment of acne, comprising the determination of the ability of a compound to modulate the expression or the activity of UDP-glucose ceramide glucosyltransferase (UGCG), and also to the use of modulators of the expression or of the activity of this enzyme for the treatment of acne or of skin disorders associated with hyperkeratinization. The invention also relates to methods for the diagnosis or prognosis, in vitro, of these pathologies.
L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'acné, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité de la UDP-glucose céramide glucosyltransférase (UGCG), ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de cette enzyme pour le traitement de l'acné ou des désordres cutanés associés à une hyperkératinisation. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de ces pathologies.
Calvo Ezequiel L.
Carlavan Isabelle
Labrie Fernand
Luu-The Van
Rivier Michel
Galderma Research & Development
Robic
LandOfFree
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