Modulatory proteins of human cns receptors

Details Modulatory proteins of human cns receptors Modulatory proteins of human cns receptors

G - Physics

01

N

G01N 33/566 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2145623

ABSTRACT Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. This neurotransmission has been found to be modulated by certain modulatory proteins. DNA coding for a family ofsuch modulatory proteins has now been isolated and the modulatory proteins have been characterized. Herein described are recombinant cell lines which produce these modulatory proteins as heterologous membrane-bound products. Also described are related aspects of the invention, which are of commercial significance, including the use of cell lines which express the modulatory proteins either homomerically, orheteromerically in a complex with an NMDA receptor, as a tool for discovery of compounds which affect the function of the modulatory proteins.

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