Mog antibodies

Details Mog antibodies Mog antibodies

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2660149

The present invention concerns in general the field of antigen-antibody-interaction-based analysis-methods and kits therefore. In particular, the present invention concerns a method for a quantitative in vitro analysis to diagnose, to categorise, to predict and/or to monitor the progression of a condition comprising contacting a sample suspected of containing anti-A-antibodies from a subject to be analysed with native and mutant antigen A, wherein the binding to mutant antigen A helps to eliminate unspecific binding to antigen A and furthermore helps to eliminate individual patient based artefacts, so that clear and unbiased data for the formation of complexes of anti-A-antibodies and antigen A are obtained. The present invention also relates to a kit for carrying out such a method. For example, the antigen is the MOG protein, and it is used as a marker for Multiple Sclerosis.

La présente invention concerne de manière générale le domaine des procédés d'analyse basés sur une interaction antigène-anticorps, et leurs kits. En particulier, la présente invention concerne un procédé pour une analyse quantitative in vitro pour diagnostiquer, catégoriser, prévoir et/ou surveiller la progression d'une condition, comprenant la mise en contact d'un échantillon suspecté de contenir des anticorps anti-A provenant d'un sujet devant être analysé avec un antigène A natif et mutant, la liaison à un antigène A mutant aidant à éliminer une liaison non spécifique à un antigène A, et aidant en outre à éliminer des artefacts basés sur un patient individuel, de sorte que des données claires et objectives pour la formation de complexes d'anticorps anti-A et d'antigène A sont obtenues. La présente invention concerne également un kit pour mettre en oeuvre un tel procédé.

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