A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
128/104, 167/159
A61K 9/00 (2006.01) A61K 9/22 (2006.01) A61K 9/70 (2006.01)
Patent
CA 1297369
ARC 1328 ABSTRACT OF THE DISCLOSURE A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reser- voir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are re- leased in a predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administra- tion over extended time periods.
539584
Lee Eun Soo
Theeuwes Felix
Wong Patrick S.l.
Yum Su Il
Zaffaroni Alejandro
Alza Corporation
Smart & Biggar
LandOfFree
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