Molecular cardiotoxicology modeling

Details Molecular cardiotoxicology modeling Molecular cardiotoxicology modeling

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2512774

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

L'invention concerne l'élucidation des changements globaux de l'expression génique et l'identification des marqueurs de toxicité dans les tissus ou les cellules exposés à une cardiotoxine connue. Les gènes peuvent être utilisés en tant que marqueurs de toxicité dans le criblage de médicaments et les dosages de toxicité. L'invention porte aussi sur une base de données de gènes caractérisés par une expression différentielle à induction de toxine qui est conçue pour être utilisée avec des micro dosages et d'autres sondes à phase solide.

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