Molecular clones of hiv-1 and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/49 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01) C12P 21/00 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2093427

The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN- ST or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such contructs. The viral isolates and envelope proteins of the present in-vention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.

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