Molecular complex and control-release of alpha hydroxyacids

Details Molecular complex and control-release of alpha hydroxyacids Molecular complex and control-release of alpha hydroxyacids

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/191 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/56 (2006.01) A61K 31/70 (2006.01) A61K 31/715 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2286730

Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release molecular complex. Such complexing agent preferably possesses one or more amino group in addition to other groups with unshared electrons such as hydroxyl, carbonyl, amido, ester and alkoxyl groups in the same molecule. Such functional groups are capable of forming multiple intermolecular hydrogen bonds with the hydroxyl groups of a free alpha hydroxyacid or related acid. The complexing agents include amino acid esters, non-amphoteric amino acid amides, aminosaccharides, aminoalditols and aminocyclitols.

On décrit des compositions pouvant former un complexe moléculaire à libération progressive. Ces compositions contiennent un alpha-hydroxyacide ou un acide voisin, et un agent complexant organique présentant un poids moléculaire compris, de préférence, entre environ 100 et 600. Ledit agent complexant organique inclut, de préférence, un ou plusieurs groupes amino en sus d'autres groupes présentant des électrons non partagés dans la même molécule, tels que les groupes hydroxyle, carbonyle, amido, ester et alcoxyle. De tels groupes fonctionnels peuvent former de multiples liaisons hydrogènes intermoléculaires avec les groupes hydroxyles d'un alpha-hydroxyacide libre ou d'un acide voisin. Les agents complexants comprennent des esters d'acide aminé, des amides d'acide aminé non amphotères, des aminosaccharides, des aminoalditols et des aminocyclitols.

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