Molecular constructs suitable for targeted conjugates

Details Molecular constructs suitable for targeted conjugates Molecular constructs suitable for targeted conjugates

C - Chemistry, Metallurgy

07

K

C07K 14/79 (2006.01) A61K 31/366 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07D 493/18 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2616906

The present invention relates generally to effective drug-linker constructs suitable for conjugation with ligands. The present invention also discloses methods of conjugating these constructs with peptides to form the compound of formula I. These methods are readily extended to any hydroxyl, amine or sulfur bearing biologically active molecules.

Cette invention concerne de façon générale des produits de synthèse entre segments de liaison et médicaments, qui sont efficaces et qui sont conçus pour être conjugués avec des ligands. Cette invention concerne également des procédés pour conjuguer ces produits de synthèse avec des peptides pour former le composé représenté par la formule (I). Ces procédés peuvent facilement s'étendre à n'importe quel groupe hydroxyle, amine ou soufre portant des molécules biologiquement actives.

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