Molecular decoyants and methods of use thereof

Details Molecular decoyants and methods of use thereof Molecular decoyants and methods of use thereof

C - Chemistry, Metallurgy

07

K

167/103

C07K 14/73 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1336489

Molecular decoyants are chemical structures which func- tionally resemble an endogenous receptor. They may be used for the treatment of humans or other animals which have been subjected to a foreign agent which exerts an undesired effect only after first binding to that endogenous receptor. A decoyant is a frac- tion of an endogenous receptor which retains the essential ele- ments of the binding site of the receptor for the foreign agent or is a synthetic or biosynthetic derivative thereof. The .alpha.-184-200 amino acid sequence of Torpedo californica acetylcholine receptor is an example of a decoyant which protects against curarimimetic neurotoxins. Another example is the fraction of the CD4 receptor which retains the essential elements of the receptor for protec- tion against HIV.

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