G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2574224
The present invention describes methods of molecular diagnosis of a concrete form of a-synucleinopathy, the dementia with Lewy bodies (DLB), associated to the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) or the alteration of its ubiquityl-ligase activity. It also refers to the use of compounds that permit the modification of the UCH-L1 levels or of the enzymatic activity of UCH-L1. This invention has application in the diagnosis and treatment of patients suffering from DLB.
La présente invention concerne des méthodes de diagnostic moléculaires applicables à une forme concrète d'.alpha.-synucléinopathie, la démence à corps de Lewy (DLB), associée à des niveaux d'ubiquitine carboxy-terminal hydrolase L1 (UCH-L1) ou à une altération de son activité d'ubiquityl-ligase. L'invention concerne également l'utilisation de composés qui permettent une modification les niveaux d'CH-L1 ou de l'activité enzymatique de UCH-L1. Cette invention convient pour le diagnostic et le traitement de patients souffrant de DLB.
Barrachina Castillo Marta
Buesa Arjol Carlos
Ferrer Abizanda Isidro
Maes Tamara
Fetherstonhaugh & Co.
Oryzon Genomics S.a.
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