Molecular dissection of the role of the pi3-kinase/akt...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/01 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2648558

This application relates to methods of inducing apoptosis in a cancerous cell, which comprise administering isolated or purified apoptin- derived peptides comprising the amino acids sequence PKPPSK.

L'apoptine est une protéine dérivé du virus de l'anémie du poulet qui tue spécifiquement des cellules cancéreuses sans toucher aux cellules normales. Nos expériences ont été réalisées dans le but d'étudier les mécanismes d'apoptose tumorale spécifique induite par l'apoptine. Cette connaissance des mécanismes est utilisée par la suite pour concevoir des peptides de l'apoptine plus courts qui seront beaucoup plus efficaces pour induire l'apoptose tout en conservant leur toxicité spécifique vis-à-vis du cancer.

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