C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2458205
Polynucleotides comprising molecular interaction sites of 23S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 23S rRNA by contacting 23S rRNA or prokaryotic cells containing the same with a compund identified by such virtual or actual screening are also provided.
La présente invention concerne des polynucléotides comprenant des sites d'interaction moléculaire de l'ARNr 23S qui possèdent une structure secondaire particulière. L'invention se rapporte également à des procédés d'utilisation de ces polynucléotides dans le criblage, virtuel ou réel, de bibliothèques combinatoires de composés qui se lient auxdits polynucléotides. L'invention concerne enfin un procédé qui permet de moduler l'activité de l'ARNr 23S en mettant en contact l'ARNr 23S ou des cellules procaryotiques le contenant avec un composé identifié par le criblage virtuel ou réel précité.
Isis Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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