C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2458228
Polynucleotides comprising molecular interaction sites of 16S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 16S rRNA by contacting 16S rRNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
L'invention concerne des polynucléotides comprenant des sites d'interaction moléculaire de ARNr 16S qui ont une structure secondaire particulière. Elle concerne également des procédés utilisant de tels polynucléotides pour cribler, éventuellement ou réellement, des bibliothèques combinatoires des composés qui s'y fixent. Elle traite en outre du procédé de modulation de l'activité de ARNr 16S par contact de ARNr 16S ou de cellules procaryotes le renfermant avec un composé identifié par un tel criblage éventuel ou réel.
Isis Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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