C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/55 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2457318
Polynucleotides comprising molecular interaction sites of RNase P RNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of RNase P RNA by contacting RNase P RNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
L'invention concerne des polynucléotides comprenant des sites d'interaction moléculaire de ARN de Rnase P qui présentent une structure secondaire particulière. L'invention concerne également des procédés permettant d'utiliser de tels polynucléotides afin de cribler, virtuellement ou réellement, des banques combinatoires de composés qui se lient à ces polynucléotides. L'invention concerne en outre un procédé permettant de moduler l'activité de ARN de RNase P par la mise en contact de celui-ci ou de cellules prokaryotiques contenant du ARN de Rnase P avec un composé identifié par un tel criblage virtuel ou réel.
Isis Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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