Molecular interactions in neurons

Details Molecular interactions in neurons Molecular interactions in neurons

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2505479

Inhibitors that disrupt binding between a PDZ protein and cognate ligands such as N-methyl-D-aspartate (NMDA) receptors that are involved in various neurological disorders are provided. Pharmaceutical compositions containing such inhibitors and their use in treating neurological diseases such as stroke and ischemia are also disclosed. Screening methods to identify additional inhibitors of specific protein ligand interactions with PDZ proteins are also described.

L'invention concerne des inhibiteurs perturbant la liaison entre une protéine PDZ et des ligands associés, notamment des récepteurs de N-méthyle-D-aspartate, impliqués dans des troubles neurologiques variés. L'invention concerne des compositions pharmaceutiques contenant ces inhibiteurs, et leur utilisation dans le traitement de maladies neurologiques, notamment l'accident vasculaire cérébral et l'ischémie. L'invention concerne des méthodes de criblage permettant d'identifier des inhibiteurs supplémentaires d'interactions de ligands protéiniques spécifiques avec des protéines PDZ.

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