Molecular model for athero/arteriosclerosis

Details Molecular model for athero/arteriosclerosis Molecular model for athero/arteriosclerosis

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/49 (2006.01)

Patent

CA 2267934

The present invention relates to a substrate being prepared by coupling of a macromolecule with the hydrophobic surface of a compound for mimicking athero/arteriosclerosis or testing athero/arteriosclerotic risk or for investigating anti-athero/arteriosclerotic effects of drug formulations. The invention relates furthermore to a process for preparing such a substrate, a method for mimicking athero/arteriosclerosis as well as to the use of the substrate for the manufacture of a test system for recognizing athero/arteriosclerotic risk or for detecting anti-athero/arteriosclerotic effects of drug formulations.

La présente invention concerne un substrat préparé en couplant une macromolécule à la surface hydrophobe d'un composé pour simuler l'athéro/artériosclérose ou tester le risque d'athéro/artériosclérose ou étudier les effets anti-athéro/artériosclérotiques des formulations des médicaments. L'invention traite également d'un procédé de préparation de ce type de substrat; d'un procédé pour simuler l'athéro/artériosclérose ainsi que de l'utilisation de ce substrat pour fabriquer un système d'essai permettant de reconnaître le risque athéro/artériosclérotique ou de détecter les effets anti-athéro/artériosclérotiques des formulations des médicaments.

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