Molecular nephrotoxicology modeling

G - Physics – 01 – N

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G01N 33/48 (2006.01)

Patent

CA 2504498

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

L'invention concerne l'élucidation des changements globaux dans l'expression génétique et l'identification de marqueurs de toxicité dans des tissus rénaux ou des cellules rénales exposés à des toxines rénales connues. Les gènes peuvent être utilisés comme marqueurs de toxicité dans le criblage de médicaments et dans des analyses de toxicité. L'invention concerne une base de données de gènes caractérisés par l'expression différentielle induite par toxines qui est conçue pour être utilisée avec des microréseaux et d'autres sondes à phase solide.

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