Molecular probing for human t-cell leukemia and lymphoma

Details Molecular probing for human t-cell leukemia and lymphoma Molecular probing for human t-cell leukemia and lymphoma

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2056998

MOLECULAR PROBING FOR HUMAN T-CELL LEUKEMIA AND LYMPHOMA Abstract A very specific area of chromosome 10. band q 11 is taught to be the site of chromosome breakpoints which occur in the course of translocations. The translocation brings sequences of the T-cell antigen receptor delta locus into adjacency with the spe- cific area on chromosome 10. The area of chromosome 10 is presumed to carry an oncogene which is activated by the proximity to the delta locus. Methods and molecular probes and primers are taught for determining the presence of this particular translo- cation.

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