Molecular signature of the pten tumor suppressor

Details Molecular signature of the pten tumor suppressor Molecular signature of the pten tumor suppressor

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2550893

The present invention relates to the identification a molecular signature for PTEN tumor suppressor. The molecular signature comprising a gene or genes that are of use for diagnosis, prognosis, drug research and development and therapeutics. Specifically, the present invention relates to identication of IGFBP2 gene, its mRNA and/or protein products that closely associate with PTEN mutations. The present invention further demonstrates that IGFBP2 expression is negatively regulated by PTEN, positively regulated by PI3K and Akt activation, that IGFBP2 plays a functional role in the PTEN signaling and is required for Akt transformation. The use of IGFBP2 gene, its gene product such as its RNA transcript, protein and molecular probes in diagnosis, prognosis, drug discovery and validation and therapeutic target and therapeutics is also contemplated.

L'invention concerne l'identification d'une signature moléculaire pour le suppresseur de tumeur PTEN. La signature comprend un gène ou des gènes utiles pour le diagnostic, le pronostic, la recherche pharmaceutique ainsi que le développement et la thérapeutique. Spécifiquement, l'invention concerne l'identification du gène IGFBP2, de son ARNm et/ou de produits protéiques étroitement associés aux mutations PTEN. L'invention montre en outre que l'expression IGFBP2 fait l'objet d'une régulation négative par le PTEN, d'une régulation positive par l'activation PI3K et Akt, que le gène IGFBP2 joue un rôle fonctionnel dans la signalisation PTEN et qu'il est nécessaire à la transformation Akt. L'invention concerne également l'utilisation du gène IGFBP2, de son produit génique du type transcription d'ARN, et de sondes protéiques et moléculaires, dans le diagnostic, le pronostic, la découverte et la validation de médicaments ou encore l'utilisation de cible thérapeutique et la thérapeutique.

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