G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2690685
The present invention relates to methods for identifying agents capable of inhibiting the expression or activity of proteins involved in the processes modulating osteoclastogenesis, which inhibition is useful in the prevention and / or treatment of bone and joint degenerative diseases and diseases involving aberrant activity or differentiation of osteoclasts. In particular, the present invention provides methods for identifying agents for use in the prevention and / or treatment of rheumatoid arthritis.
La présente invention porte sur des procédés pour identifier des agents capables d'inhiber l'expression ou l'activité de protéines mises en jeu dans les procédés modulant l'ostéoclastogenèse, laquelle inhibition s'utilise dans la prévention et/ou le traitement de maladies dégénératives des os et des articulations, et de maladies mettant en jeu une activité ou une différenciation aberrante des ostéoclastes. En particulier, la présente invention propose des procédés pour identifier des agents pour une utilisation dans la prévention et/ou le traitement de la polyarthrite rhumatoïde.
Brys Reginald Christophe Xavier
Vandeghinste Nick Ernest Rene
Galapagos N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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