Molecular toxicology modeling

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2447357

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

L'invention est basée sur l'élucidation des changements globaux intervenant dans l'expression génique et l'identification des marqueurs de toxicité dans les tissus ou les cellules exposés à une toxine rénale connue. Les gènes peuvent être utilisés comme marqueurs de toxicité dans la sélection des médicaments et les dosages de toxicité. L'invention comprend une base de données de gènes caractérisée par l'expression différentielle provoquée par une toxine qui est prévue pour l'utilisation avec des micro-arrangements et autres sondes à phase solide.

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