C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2417214
This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising endoplasmic reticulum chaperone polypeptides and antigenic peptides. In particular, the invention provides compositions and methods for enhancing immune responses induced by polypeptides made in vivo by administered nucleic acid, such as naked DNA or expression vectors, encoding the chimeric molecules. The invention provides a method of inhibiting the growth of a tumor in an individual. The invention also provides novel self-replicating RNA virus constructs for enhancing immune responses induced by chimeric polypeptides made in vivo.
L'invention concerne des compositions et des procédés permettant d'induire et de renforcer des réponses immunes, par exemples des réponses de lymphocytes T cytotoxiques spécifiques des antigènes, à l'aide de molécules chimériques comportant des polypeptides chaperons du réticulum endoplasmique et des peptides antigènes. En particulier, l'invention concerne des compositions et des procédés permettant de renforcer les réponses immunes induites par des polypeptides produits in vivo par administration d'acide nucléique, par exemple ADN nu ou des vecteurs d'expression, codant les molécules chimériques. L'invention concerne également un procédé permettant d'inhiber la croissance d'une tumeur chez le patient. Elle concerne enfin de nouvelles constructions de virus ARN autoreproducteurs destinées à renforcer les réponses immunes induites par des polypeptides chimériques produits in vivo.
Hung Chien-Fu
Wu Tzyy-Choou
Johns Hopkins University
Smart & Biggar
LandOfFree
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