Molecule labelling using 2-hydrazinopyridine derivatives

Details Molecule labelling using 2-hydrazinopyridine derivatives Molecule labelling using 2-hydrazinopyridine derivatives

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 51/10 (2006.01) C07D 213/78 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07K 1/13 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2148595

Novel bifunctional hydrazine derivatives of general formula (I), where E is alkenyl or H2, J is -CONH-, -COO-, -COS- or -NHCO-, T is alkylene or if J is -CONH-, T is the residue of an amino acid moiety, Q is a hydrophilic or cleavable moiety, and Z is an amine- and/or thiol-reactive moiety, are useful linker molecules for attaching metal ions such as 99m Tc to macromolecules such a MAB's or MAB fragments.

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