C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2700433
The invention discloses LRP6 agonizing or antagonizing binding molecules (e.g., antibodies or a Fab fragments), and their use to facilitate or inhibit Wnt pathway signaling, respectively. Said LRP6 agonizing or antagonizing binding molecules can be used to e.g., diagnose, ameliorate the symptoms of, protect against, and treat Wnt signaling disorders associated with aberrantly low or aberrantly high levels of Wnt pathway signaling, respectively. Non- limiting examples of disorders which can be treated associated with aberrant upregulation of Wnt signaling is cancer (e.g., colon cancer). Non-limiting examples of disorders which can be diagnosed, protected against, and treated include cancers, bone disorders (e.g., osteoporosis and osteoarthritis), diabetes, neurodegenerative diseases such as Alzheimer's disease, and fibrotic disorders.
L'invention porte sur des molécules agonisantes ou antagonisantes de fixation à la LRP6 (par exemple anticorps ou fragments Fab), et sur leur utilisation pour favoriser ou inhiber la signalisation par le mécanisme Wnt. Lesdites molécules de fixation à la LRP6 peuvent par exemple servir à diagnostiquer ou améliorer les symptômes, protéger contre ou traiter les troubles de la signalisation par le mécanisme Wnt associés à une signalisation anormalement haute ou anormalement basse. Parmi les exemples non limitatifs de troubles associés à une surrégulation aberrante de la signalisation par le Wnt pouvant être traités, figure le cancer (par exemple le cancer du colon). Parmi les exemples non limitatifs de troubles pouvant être diagnostiqués, objets de protection et traités figurent les cancers, les maladies de l'os (par exemple ostéoporose et ostéoarthrite), le diabète, les maladies neurodégénératives telles que la maladie d'Alzheimer et les troubles fibrotiques.
Cong Feng
Ettenberg Seth
Guth Sabine
Rangwala Shamina M.
Fetherstonhaugh & Co.
Novartis Ag
LandOfFree
Molecules and methods for modulating low-density-lipoprotein... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Molecules and methods for modulating low-density-lipoprotein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecules and methods for modulating low-density-lipoprotein... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1579164