Molecules and methods of using same for treating ccr5/ccr5...

Details Molecules and methods of using same for treating ccr5/ccr5... Molecules and methods of using same for treating ccr5/ccr5...

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2639115

Soluble molecules are provided. Thus, for example, provided is a soluble molecule which comprises a heterologous amino acid sequence conjugated to a CCR5 amino acid sequence being capable of binding a CCR5 ligand, and wherein the molecule is devoid of an N-terminus domain of CCR5. Also provided are pharmaceutical compositions which comprise the above molecules and methods and uses of same.

L'invention concerne des molécules solubles. Elle concerne par exemple une molécule soluble qui comprend une séquence d'acides aminés hétérologue conjuguée à une séquence d'acides aminés du CCR5 capable de se lier à un ligand du CCR5, ladite molécule étant dépourvue de domaine N-terminal du CCR5. L'invention concerne également des compositions pharmaceutiques qui comprennent les molécules précitées, ainsi que des méthodes pour les utiliser et leurs utilisations.

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