Molecules for diagnostics and therapeutics

Details Molecules for diagnostics and therapeutics Molecules for diagnostics and therapeutics

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2401868

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.

La présente invention concerne des polynucléotides humains purifiés utilisés à des fins diagnostiques et thérapeutiques (dithp). Elle se rapporte également aux polypeptides (DITHP) codés par ces dithp, ainsi qu'à l'utilisation de ces dithp ou de leurs compléments, oligonucléotides ou fragments dans des analyses diagnostiques. L'invention concerne en outre des vecteurs et des cellules hôtes contenant ces dithp et permettant l'expression de DITHP. Elle concerne notamment l'utilisation de DITHP isolés et purifiés pour l'induction d'anticorps et pour le criblage de banques de composés, ainsi que l'utilisation d'anticorps anti-DITHP dans des analyses diagnostiques. L'invention se rapporte enfin à des jeux ordonnés de microéchantillons contenant ces dithp ainsi qu'à leurs procédés d'utilisation.

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