C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2401076
The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce anitbodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.
La présente invention concerne des polynucléotides moléculaires purifiés destinés au traitement et à la détection de maladies (mddt). L'invention concerne également des polypeptides (MDDT) codés par mddt ainsi que l'utilisation de mddt, ou de compléments, d'oligonucléotides ou de fragments de ces derniers dans des méthodes diagnostiques. L'invention concerne en outre des vecteurs et des cellules hôtes renfermant mddt pour l'expression de MDDT ainsi que l'utilisation de MDDT isolés et purifiés afin d'induire des anticorps et de cribler des banques de composés, et l'utilisation d'anticorps anti-MDDT dans des méthodes diagnostiques. L'invention concerne par ailleurs des jeux ordonnés de microéchantillons renfermant mddt et des procédés d'utilisation.
Amshey Stefan
Banville Steven C.
Bradley Diana L.
Bratcher Shawn R.
Chalup Michael S.
Incyte Genomics Inc.
Smart & Biggar
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