Molecules for disease detection and treatment

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2433753

The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.

La présente invention concerne des polynucléotides (mddt) de molécules de détection et de traitement de maladies purifiés. L'invention concerne également les polypeptides (MDDT) codés par les mddt. En outre, cette invention concerne l'utilisation des polynucléotides mddt, ou de compléments, d'oligonucléotides, ou de fragments de ceux-ci dans des dosages diagnostiques. De plus, l'invention concerne des vecteurs et des cellules hôtes contenant les polynucléotides mddt pour l'expression de MDDT. L'invention concerne également l'utilisation de MDDT isolés et purifiés pour induire des anticorps et pour le criblage de bibliothèques de composés, et l'utilisation d'anticorps dirigés contre les MDDT dans des dosages diagnostiques. Sont également décrits des microréseaux contenant les polynucléotides mddt et leurs procédés d'utilisation.

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