C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2420983
The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.
L'invention concerne des polynucléotides sous forme de molécules purifiées permettant la détection et le traitement de maladies (mddt). L'invention concerne également des polypeptides (MDDT) codés par ces mddt. L'invention concerne par ailleurs l'utilisation des éléments suivants dans des épreuves diagnostiques: mddt, ou compléments, oligonucléotides, ou fragments. L'invention concerne en outre des vecteurs et des cellules hôtes renfermant des mddt, pour l'expression des MDDT. L'invention concerne enfin l'utilisation de MDDT isolés et purifiés pour l'induction d'anticorps et le criblage de librairies de composés, l'utilisation d'anticorps anti-MDDT dans des épreuves diagnostiques, ainsi que des jeux ordonnés de microéchantillons et des procédés d'utilisation correspondants.
Altus Christina M.
Au Alan P.
Bradley Diana L.
Chalup Michael S.
Chang Simon C.
Incyte Genomics Inc.
Smart & Biggar
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