C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2385791
The present invention provides purified disease detection and treatment molecule pulynucleotides (mddt). Also encompassed are the polypeplides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements. oligonucleotides, or fragment thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the of isolated and purified MMDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.
L'invention concerne des polynucléotides purifiés de molécules de détection et de traitement de maladies (mddt). L'invention concerne également les polypeptides (MDDT) codés par mddt, ainsi que l'utilisation des mddt, ou des compléments, oligonucléotides ou fragments de ces derniers dans des méthodes diagnostiques. L'invention concerne en outre des vecteurs et des cellules hôtes contenant mddt pour l'expression de MDDT. L'invention concerne encore l'utilisation de MDDT isolés et purifiés afin d'induire des anticorps et de cribler des banques de composés, et l'utilisation d'anticorps anti-MDDT dans des méthodes diagnostiques. L'invention concerne par ailleurs des microéchantillons contenant mddt et des procédés d'utilisation.
Amshey Stefan
Banville Steven C.
Bratcher Shawn R.
Chalup Michael S.
Chen Wensheng
Incyte Genomics Inc.
Smart & Biggar
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