A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 5/00 (2006.01) A61P 19/00 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2693048
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.
La présente invention concerne des conjugués, comprenant un organe, un tissu ou une molécule se logeant dans une cellule tumorale lié à un fragment. Un tel fragment peut être, par exemple, un oligonucléotide, un petit ARN interférent, un gène, un virus, une protéine, un agent pharmaceutique ou un agent détectable. En outre, l'invention concerne des procédés destinés à diagnostiquer ou à traiter une pathologie du muscle ou du cur par l'administration, à un sujet souffrant ou susceptible de souffrir d'une pathologie, d'une molécule ou d'un conjugué qui se loge, se lie et est absorbé par les cellules musculaires ou cardiaques.
Heemskerk Johannes Antonius
Platenburg Gerard Johannes
Van Deutekom Judith Christina Theodora
Van Kuik-Romeijn Petra
Prosensa Technologies B.v.
Ridout & Maybee Llp
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