Molecules interacting with apoptin

Details Molecules interacting with apoptin Molecules interacting with apoptin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311611

The invention relates to activation of apoptosis by means of interference of Hou-like and/or IFP35-like compounds. Also the invention relates to anti-tumor therapies with compounds, which negatively interfere with Hou-like and/or IFP35-like compounds leading to induction of apoptosis, resulting in the elimination of tumor cells. Also the invention relates to therapies for diseases related to aberrant apoptosis induction, such as auto-immune disease. Also the invention describes the diagnosis of cells, which are susceptible to apoptin- or apoptin-like induced apoptosis.

L'invention porte sur l'activation de l'apoptose par l'interférence de composés de type Hou et/ou de type IFP35. L'invention porte également sur des thérapies antitumorales utilisant des composés qui interfèrent négativement avec des composés de type Hou et/ou IFP35 conduisant à l'induction de l'apoptose et entraînant l'élimination des cellules tumorales. L'invention porte encore sur des thérapies s'appliquant aux maladies apparentées à l'induction de l'apoptose aberrante telles que des maladies autoimmunes. L'invention porte enfin sur le diagnostic des cellules sensibles à l'apoptose induite par l'apoptine ou une protéine analogue à l'apoptine.

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