Molecules with antibody combining sites that exhibit...

Details Molecules with antibody combining sites that exhibit... Molecules with antibody combining sites that exhibit...

A - Human Necessities

61

K

195/1.112

A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07B 63/00 (2006.01) C07C 233/54 (2006.01) C07D 207/46 (2006.01) C07D 215/32 (2006.01) C07D 215/40 (2006.01) C07D 311/16 (2006.01) C07F 9/40 (2006.01) C07F 9/42 (2006.01) C07F 9/553 (2006.01) C07F 9/58 (2006.01) C07F 9/60 (2006.01) C07F 9/6558 (2006.01) C07K 16/44 (2006.01) C12N 9/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 1312835

ABSTRACT OF THE DISCLOSURE An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site. 7889M D-48S

546973

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