Monitor protein for measuring protein phosphorylation

Details Monitor protein for measuring protein phosphorylation Monitor protein for measuring protein phosphorylation

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) C07K 14/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2341153

A phosphorylation monitor protein by which the phosphorylation in a phosphorylation region can be conveniently monitored has been successfully constructed by using a protein containing the phosphorylation region and a characteristic-variable region wherein characteristics vary due to a change in the three-dimensional structure. As a result, there has been developed a system for analyzing protein phosphorylation which is free from any radioisotope and applicable also to the measurement in vivo. This analytical system is usable not only in detecting a phosphorylation reaction but also in screening a kinase or a compound promoting or inhibiting phosphorylation.

L'invention concerne une protéine de surveillance de phosphorylation permettant de surveiller de manière appropriée la phosphorylation dans une région de phosphorylation, qui a été élaborée avec succès au moyen d'une protéine contenant la région de phosphorylation et une région à caractéristiques variables, ces caractéristiques variant en raison d'une modification de structure tridimensionnelle. Par conséquent, un système permettant d'analyser la phosphorylation de protéines a été mis au point, ce système étant exempt de radio-isotope et pouvant également être appliqué à des mesures in vivo. Ce système analytique peut être utilisé non seulement pour détecter une réaction de phosphorylation, mais aussi pour cribler une kinase ou un composé favorisant ou inhibant la phosphorylation.

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