G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01)
Patent
CA 2735239
Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1(HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
La présente invention concerne des compositions et des procédés destinés à moduler une infection par le virus de limmunodéficience humaine (VIH) qui impliquent des substances qui inhibent la capacité de la protéine HMGB1 (high mobility box 1) à interagir avec les cellules tueuses naturelles (NK). La présente invention concerne également des compositions thérapeutiques comprenant des anticorps et des médicaments, tels que la glycyrrhizine, qui se lient à HMGB1. La présente invention concerne en outre des procédés de détection ou de surveillance dune infection par le VIH impliquant la détection ou la quantification de HMGB1 ou danticorps spécifiques de HMGB1 dans un échantillon biologique.
Gougeon Marie-Lise
Melki Maria-Therese
Poirier-Beaudoin Beatrice
Saidi Hela
Seffer Valerie
Institut Pasteur
Smart & Biggar
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