G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/487 (2006.01) G01N 33/50 (2006.01) G01N 33/539 (2006.01) G01N 33/573 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2318776
The present invention is a method for drug level detection by using a simplified and effective deproteinizing step from body fluids, such as plasma, blood, urine, saliva, tear fluid, followed by drug extraction and measurement using an accurate technique, such as a colorimetric assay or a High- Performance Liquid Chromatography method. In a particular embodiment, the invention is directed to a method to quantify rifampicin in order to monitor its levels in body fluids and also to a Kit for rifampicin concentration measurement.
L'invention concerne un procédé permettant de détecter un niveau de médicament à l'aide d'une étape de déprotéinisation efficace simplifiée à partir de fluides corporels, tels que le plasma, le sang, l'urine, la salive, le fluide lacrymal, suivie de l'extraction et du dosage du médicament à l'aide d'une technique précise, telle qu'un dosage colorimétrique ou un procédé de chromatographie liquide haute performance. Selon un mode de réalisation particulier, l'invention concerne un procédé permettant de quantifier la rifampicine, afin de surveiller ses niveaux dans les fluides corporels, ainsi qu'un kit permettant de mesurer la concentration de ladite rifampicine.
Barroso Eduardo Werneck
Filho Milton Ferreira
Gemal Andre Luis
Luiza Vera Lucia
Fiocruz Fundacao Oswaldo Cruz
Gowling Lafleur Henderson Llp
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