C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2223532
The present invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening of phase display libraries or monkey heterohybridomas obtained using B lymphocytes from B7.1 and/or B7.2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three primatized antibodies derived from those monkey monoclonal antibodies which bind B7.1 and possibly B7.2, primatized 7C10, primatized 7B6 and primatized 16C10. These primatized and monkey antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
L'invention concerne l'identification d'anticorps de macaques dirigés contre le B7.1 et B7.2 humains par criblage de bibliothèques de phages ou d'hétérohybridomes simiens obtenus par utilisation de lymphocytes B prélevés sur des singes immunisés contre le B7.1 et/ B7.2. Plus spécifiquement, l'invention concerne quatre anticorps monoclonaux simiens 7B6, 16C10, 7C10 et 20C9 qui inhibent la voie B7:CD28 et agissent par conséquent efficacement comme immunosuppresseurs. L'invention concerne en outre les séquences complètes d'ADN et d'acides aminés des chaînes légère et lourde des trois anticorps adaptés aux primates dérivés de ces anticorps monoclonaux simiens qui se lient au B7.1 et éventuellement au B7.2, au 7C10 adapté aux primates, au 7B6 adapté aux primates et au 16C10 adapté aux primates. On peut utiliser ces anticorps simiens et adaptés aux primates comme immunosuppresseurs spécifiques, par exemple pour traiter des maladies auto-immunes et pour prévenir le rejet d'organes transplantés.
Anderson Darrell R.
Brams Peter
Hanna Nabil
Shestowsky William S.
Biogen Idec Inc.
Idec Pharmaceuticals Corporation
Smart & Biggar
LandOfFree
Monkey monoclonal antibodies specific to human b7.1 and/or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monkey monoclonal antibodies specific to human b7.1 and/or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monkey monoclonal antibodies specific to human b7.1 and/or... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1481256