Mono- and bis-indolylquinones and prophylactic and...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 209/12 (2006.01) A61K 31/404 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) C07D 209/42 (2006.01)

Patent

CA 2385105

The present invention relates to a class of indolylquinone compounds that inhibit GRB-2 adaptor protein function, pharmaceutical compositions comprising these compounds, and methods for ameliorating the symptoms of cell proliferative disorders associated with GRB-2 adaptor protein function using these compounds. The present invention further relates to methods for treating insulin-related disorders, such as diabetes, insulin resistance, insulin deficiency and insulin allergy, and for ameliorating the symptoms of insulin- related disorders, using certain indolylquinone compounds and pharmaceutical compositions thereof. The present invention also relates to novel synthetic methods for the preparation of mono- and bis-indolylquinone compounds.

La présente invention concerne une classe de composés indolylquinone qui inhibe la fonction protéique adaptatrice GRB-2, des compositions pharmaceutiques comprenant ces composés, et des techniques permettant d'améliorer les symptômes de la prolifération cellulaire pathologique associées à la fonction protéique adaptatrice GRB-2 par l'utilisation de ces composés. Cette invention concerne aussi Des techniques permettant de traiter des pathologies liées à l'insuline, telle que le diabète, l'insulino-résistance, l'insulino-déficience et l'allergie à l'insuline, et d'améliorer les symptômes de pathologies liées à l'insuline, par l'utilisation de certains composés indolylquinone et de compositions pharmaceutiques de ceux-ci. Enfin, cette invention concerne de nouvelles techniques synthétiques de préparation de composés mono-indolylquinones et bi-indolylquinones.

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