Mono and combination therapy with m1/m4 muscarinic agonist...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/439 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2649590

The invention relates to the use of a functional muscarinic M1/M4 agonist or a pharmaceutically acceptable salt thereof to treat prodromal syndrome and in the manufacture of a medicament for the treatment of prodromal syndrome, and to a method of treatment of prodromal syndrome using a functional muscarinic M1/M4 agonist or a pharmaceutically acceptable salt thereof. It also relates to the use of a pharmaceutical composition comprising a functional muscarinic M1/M4 agonist or a pharmaceutically acceptable salt thereof, and at least one cholinergic agent and/or at least one non-cholinergic agent for the treatment of prodromal syndrome, and to a method of treatment of prodromal syndrome by administration of a such a pharmaceutical composition.

L'invention porte sur l'utilisation d'un agoniste muscarinique M1/M4 fonctionnel ou d'un sel pharmaceutiquement acceptable de celui-ci dans le traitement d'un syndrôme prodromique et dans la fabrication d'un médicament traitant le syndrôme prodromique et un procédé de traitement d'un syndrome prodromique à l'aide d'un agoniste muscarinique M1/M4 fonctionnel ou d'un sel pharmaceutiquement acceptable de celui-ci. Elle porte également sur l'utilisation d'une composition pharmaceutique comprenant un agoniste muscarinique M1/M4 fonctionnel ou un sel pharmaceutiquement acceptable de celui-ci et au moins un agent cholinergique et/ou au moins un agent non cholinergique permettant le traitement d'un syndrôme prodromique et sur un procédé de traitement d'un syndrôme prodromique par l'administration d'une telle composition pharmaceutique.

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