Mono- and disubstituted 3-propyl gamma-aminobutyric acids

Details Mono- and disubstituted 3-propyl gamma-aminobutyric acids Mono- and disubstituted 3-propyl gamma-aminobutyric acids

C - Chemistry, Metallurgy

07

C

C07C 229/08 (2006.01) A61K 31/197 (2006.01) A61P 1/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2374755

The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula (I). The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

La présente invention concerne une série de nouveaux acides 3-propyle gamma aminobutyriques monosubstitués et disubstitués de formule (I). Ces composés sont utilisés comme agents thérapeutiques visant à traiter l'épilepsie, les attaques de lipothymie, l'hypocinésie, les troubles crâniens, les troubles neurodégénératifs, la dépression, l'anxiété, la panique, la douleur, les troubles neuropathologiques, l'arthrite, les troubles du sommeil, le côlon irritable et les lésions gastriques. En outre, cette invention concerne la préparation de ces composés, ainsi que des intermédiaires utiles.

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