C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/473 (2006.01) A61K 31/4743 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 221/18 (2006.01)
Patent
CA 2476115
Mono-ester and asymmetrically substituted diesters of dihydrexidine, dinapsoline and A-86929 and substituted derivatives thereof are described. The novel ester/diester derivatives exhibit improved pharmacokinetic characteristics relative to their unesterified parent compounds and can be formulated into pharmaceutical compositions useful for the treatment of a wide variety of dopamine related disorders.
L'invention concerne un monoester et des diesters à substitution asymétrique de la dihydrexidine, de la dinapsoline et de A-86929 et leurs dérivés substitués. Ces nouveaux dérivés d'ester et de diester présentent des caractéristiques pharmacocinétiques améliorées par rapport à leurs composés d'origine non estérifiés et peuvent être élaborés sous forme de compositions destinées au traitement d'un grand nombre de troubles liés à la dopamine.
Dijkstra Durk
Wikstrom Hakan
Darpharma Inc.
Smart & Biggar
LandOfFree
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