Mono-hydrochloric salts of an inhibitor of histone deacetylase

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/26 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2683195

This invention provides novel crystalline forms of mono-HCl salts and a mono-HCl salt hydrate of JNJ-26481585, an inhibitor of histone deacetylases. The invention also relates to processes for production of these forms, to intermediates used in these processes, to pharmaceutical compositions comprising these forms, and to the use of these forms in medical treatment for instance as a medicine to inhibit proliferative conditions, such as cancer and leukemia.

Cette invention porte sur de nouvelles formes cristallines de sels mono-HCl et d'un hydrate du sel mono-HCl de JNJ-26481585, un inhibiteur d'histones désacétylases. L'invention porte également sur des procédés de fabrication de ces formes, sur des intermédiaires utilisés dans ces procédés, sur des compositions pharmaceutiques comprenant ces formes, et sur l'utilisation de ces formes dans un traitement médical, par exemple, en tant que médicament pour inhiber des états prolifératifs, tels que le cancer et la leucémie.

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