C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4196 (2006.01) A61K 31/427 (2006.01) A61P 31/04 (2006.01) C07C 229/26 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2606185
Mono-lysine salts of triazole compounds having a secondary or tertiary hydroxy group are provided. More particularly, the new water-soluble triazole antifungal mono-lysine salt compounds, or solvates thereof, are provided having the general formula I: wherein A in formula I represents the non- hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group. R and R1 in formula I can each be a hydrogen atom or an alkyl group having one to six carbon atoms. The novel water-soluble azole compounds are useful for the treatment of fungal infections and can be administered orally, topically and parenterally.
L'invention concerne des sels mono-lysines de composés triazoles possédant un groupe hydroxy secondaire ou tertiaire. Plus spécifiquement, l'invention concerne de nouveaux composés de sels mono-lysines antifongiques hydrosolubles, ou des solvates de ceux-ci, représentés par la formule générale (I), dans laquelle A représente la partie non hydroxy d'un composé antifongique triazole du type contenant un groupe hydroxyle secondaire ou tertiaire, R et R1 peuvent chacun représenter un atome d'hydrogène ou un groupe alkyle possédant de un à six atomes de carbone. Ces nouveaux composés azoles hydrosolubles sont utiles dans le traitement d'infections fongiques et peuvent être administrés par voie orale, de façon topique ou de façon parentérale.
Chen Chung-Pin H.
Fakes Michael G.
Gao Qi
Kiau Susanne
Pendri Yadagiri R.
Eisai R&d Management Co. Ltd.
Gowling Lafleur Henderson Llp
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